Editor's Choice
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Open Access Review
Narcotics and breast surgery: a review of current literature
Melissa Hite, ... Andrea M. AbbottOpioid consumption in the United States is the highest of all nations, with 42,000 people dying from opioid overdose in 2016. Patients with breast cancer undergoing curative-intent surgery are particularly vulnerable to developing persistent opioid use. It is anticipated that postoperatively... Read More >This article belongs to the Special Issue Caring for patients with breast cancerJ Unexplored Med Data 2019;4:9.Published on: 18 Nov 2019 Viewed: 117 Downloaded: 58 -
Open Access Original Article
Exemestane leads to hormone-associated ascites in female hamsters with experimental metabolic syndrome
Dmytro Lytkin, ... Tatiana BriukhanovaAim: During the study of the aromatase inhibitors effect on metabolic disorders, it was found that exemestane significantly caused ascites. This part of pre-clinical study aimed to investigate the potential dysregulatory effect of exemestan on adrenal synthesis of hormones with... Read More >This article belongs to the Special Issue Caring for patients with breast cancerJ Unexplored Med Data 2019;4:8.Published on: 17 Sep 2019 Viewed: 343 Downloaded: 168 -
Open Access Perspective
Platelet aerobic metabolism: new perspectives
Silvia Ravera, Isabella PanfoliAlthough the role of platelets in hemostasis and thrombotic disorders as well as their contribution to inflammation are known, recent studies support the notion that much remains to be learned about platelet bioenergetics. Recent data suggest that platelets possess extra-mitochondrial oxidative... Read More >This article belongs to the Special Issue New frontiers in platelet functionJ Unexplored Med Data 2019;4:7.Published on: 11 Sep 2019 Viewed: 304 Downloaded: 179 -
Open Access Original Article
The quest for reliable prediction of chemotherapy-induced delayed nausea among breast cancer patients
Dillon D. McCourt, ... U. Margaretha WallonAim: Though female sex is considered a risk factor when predicting chemotherapy-induced nausea, not all women will experience nausea. Therefore, the aim of this pilot study was to evaluate the accuracy, and usefulness, of a blood-based assay for predicting chemotherapy-induced delayed nausea... Read More >This article belongs to the Special Issue Caring for patients with breast cancerJ Unexplored Med Data 2019;4:6.Published on: 21 Jun 2019 Viewed: 1033 Downloaded: 101 -
Open Access Review
Lymphedema after treatment of breast cancer: a comprehensive review
Kareen Ayre, Catherine ParkerLymphedema is a chronic and morbid complication that can result from breast cancer treatment involving surgery and/or radiation therapy. Breast cancer related lymphedema (BCRL) can result in functional and psychological problems that can affect a patient’s quality of life. Lymphedema is a... Read More >This article belongs to the Special Issue Caring for patients with breast cancerJ Unexplored Med Data 2019;4:5.Published on: 13 Jun 2019 Viewed: 1239 Downloaded: 124 -
Open Access Review
Platelet-derived vesicles: diagnostic and predictive value in cardiovascular diseases
Alexander E. Berezin, Alexander A. BerezinThere is emerging evidence that endogenous microvesicles released by platelets may play a pivotal role in pathogenesis of numerous diseases including stable and unstable ischemic heart disease, atherosclerosis, hypertension, idiopathic pulmonary hypertension, atrial fibrillation/flutter, acute... Read More >This article belongs to the Special Issue New frontiers in platelet functionJ Unexplored Med Data 2019;4:4.Published on: 15 May 2019 Viewed: 1094 Downloaded: 145
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Open Access Original Article
In vivo anticancer efficacy assessment with an imaging-based platform: taking Brucea Javanica oil emulsion as an example
Ye-Wei Liu, ... Yi-Cheng NiAim: Brucea Javanica oil emulsion (BJOE) has already been commercialized to treat various malignancies. The authors verified BJOE for its therapeutic effects on rhabdomyosarcoma (R1) in rats using magnetic resonance imaging (MRI), microangiography and histopathology. Methods: Rats were... Read More >J Unexplored Med Data 2016;1:21-9.Published on: 13 Sep 2016 Viewed: 56616 Downloaded: 531 -
Open Access Original Article
Safety and efficacy of biweekly cetuximab based chemotherapy for patients with metastatic colorectal cancer
Jamal Zekri, ... Rasha HaggagAim: Cetuximab was administered weekly in registration clinical trials. Biweekly administration is more convenient when combining cetuximab with biweekly chemotherapy in patients with metastatic colorectal cancer (mCRC). The aim of this study is to evaluate safety and efficacy of biweekly... Read More >J Unexplored Med Data 2016;1:15-20.Published on: 13 Sep 2016 Viewed: 36787 Downloaded: 2504 -
Open Access Review
Surgical outcomes of distal splenorenal shunt or liver transplantation in treatment of schistosomal refractory variceal bleeding
Wael Mohialddin Ahmed Doush, Juhaina Ahmed ElzeinSchistosomiasis is one of the most prevalent neglected tropical diseases, remains a serious public health problem in many developing countries in the tropics and subtropics and its pathogenesis depends on the parasite-host interaction. Periportal fibrosis of schistosomiasis complicated by... Read More >J Unexplored Med Data 2018;3:2.Published on: 30 Jan 2018 Viewed: 15185 Downloaded: 509 -
Open Access Review
Immunotherapy in head and neck tumors: new options in advanced disease and beyond
Nicole B. Quenelle, Carrie L. CostantiniThis article aims to review the role of immunotherapy in tumors of the head and neck, focusing primarily on US Food and Drug Administration (FDA) approved checkpoint inhibitors in squamous cell histology. The data showing superiority of checkpoint inhibitors over cytotoxic chemotherapy that led... Read More >This article belongs to the Special Issue Immunotherapy as a new hope against solid tumorsJ Unexplored Med Data 2018;3:7.Published on: 31 Aug 2018 Viewed: 10409 Downloaded: 502 -
Open Access Review
The role of plant-based nutrition in cancer prevention
Mariah Madigan, Elisa KarhuPlant-based nutrition has been shown to protect against the 15 leading causes of death in the world, including many cancers, and may offer benefits as a disease modifying tool to improve the management and treatment of these conditions. Results on the effects of plant-based nutrition on breast,... Read More >J Unexplored Med Data 2018;3:9.Published on: 8 Nov 2018 Viewed: 8590 Downloaded: 678 -
Open Access Original Article
Knowledge, awareness, and practice of forensic odontology among dental surgeons in Bhubaneswar, India
Juber Rahman, ... Narayan SuklaAim: The aim of the study was to evaluate knowledge, awareness, and practice related to forensic odontology among dental surgeons in Bhubaneswar, East India. Methods: A blind cross-sectional study, using a questionnaire with close-ended questions, was carried out. Interns were included to... Read More >J Unexplored Med Data 2017;2:26-33.Published on: 21 May 2017 Viewed: 8500 Downloaded: 1090
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Open Access Original Article
Safety and efficacy of biweekly cetuximab based chemotherapy for patients with metastatic colorectal cancer
Jamal Zekri, ... Rasha HaggagAim: Cetuximab was administered weekly in registration clinical trials. Biweekly administration is more convenient when combining cetuximab with biweekly chemotherapy in patients with metastatic colorectal cancer (mCRC). The aim of this study is to evaluate safety and efficacy of biweekly... Read More >J Unexplored Med Data 2016;1:15-20.Published on: 13 Sep 2016 Viewed: 36787 Downloaded: 2504 -
Open Access Original Article
Knowledge, awareness, and practice of forensic odontology among dental surgeons in Bhubaneswar, India
Juber Rahman, ... Narayan SuklaAim: The aim of the study was to evaluate knowledge, awareness, and practice related to forensic odontology among dental surgeons in Bhubaneswar, East India. Methods: A blind cross-sectional study, using a questionnaire with close-ended questions, was carried out. Interns were included to... Read More >J Unexplored Med Data 2017;2:26-33.Published on: 21 May 2017 Viewed: 8500 Downloaded: 1090 -
Open Access Review
Zebrafish as screening model for detecting toxicity and drugs efficacy
Maria Virginia Caballero, Manila CandiracciEmbryonic and larval Danio rerio (zebrafish) is increasingly used as a toxicological model to conduct rapid in vivo tests and developmental toxicity assays; the zebrafish features high genetic homology to mammals, robust, phenotypes, high-throughput genetic and chemical screening have made... Read More >J Unexplored Med Data 2018;3:4.Published on: 10 Feb 2018 Viewed: 7856 Downloaded: 852 -
Open Access Review
The role of plant-based nutrition in cancer prevention
Mariah Madigan, Elisa KarhuPlant-based nutrition has been shown to protect against the 15 leading causes of death in the world, including many cancers, and may offer benefits as a disease modifying tool to improve the management and treatment of these conditions. Results on the effects of plant-based nutrition on breast,... Read More >J Unexplored Med Data 2018;3:9.Published on: 8 Nov 2018 Viewed: 8590 Downloaded: 678 -
Open Access Original Article
Molecular characterization of cancer-associated fibroblasts isolated from human colorectal cancer as a major stromal cell component promoting metastasis
Pravin D. Potdar, Shahid ChaudharyAim: Colorectal cancer (CRC) remains a disease with poor prognosis and limited overall 5-year survival rate, which highlights a clear clinical need for novel treatment strategies. The stromal cancer-associated fibroblasts (CAFs) strongly dictate the metastatic potential of CRC and hence... Read More >J Unexplored Med Data 2017;2:1-8.Published on: 9 Feb 2017 Viewed: 5095 Downloaded: 646 -
Open Access Minireview
Treatment of epidermal growth factor receptor mutations in non-small cell lung cancer: current role and the future perspective
Yasar Ahmed, Harliana YousifManaging advanced non-small cell lung cancer has become far more complex than in the past. This in part is due to the fact that advances in molecular oncology allow for far more refined and effective treatment options for many lung cancer patients. One of the first advances was the... Read More >J Unexplored Med Data 2017;2:39-47.Published on: 6 Jul 2017 Viewed: 6499 Downloaded: 622
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Open Access Review
Zebrafish as screening model for detecting toxicity and drugs efficacy
Maria Virginia Caballero, Manila CandiracciEmbryonic and larval Danio rerio (zebrafish) is increasingly used as a toxicological model to conduct rapid in vivo tests and developmental toxicity assays; the zebrafish features high genetic homology to mammals, robust, phenotypes, high-throughput genetic and chemical screening have made... Read More >J Unexplored Med Data 2018;3:4.Published on: 10 Feb 2018 Viewed: 7856 Downloaded: 852 -
Open Access Review
The role of plant-based nutrition in cancer prevention
Mariah Madigan, Elisa KarhuPlant-based nutrition has been shown to protect against the 15 leading causes of death in the world, including many cancers, and may offer benefits as a disease modifying tool to improve the management and treatment of these conditions. Results on the effects of plant-based nutrition on breast,... Read More >J Unexplored Med Data 2018;3:9.Published on: 8 Nov 2018 Viewed: 8590 Downloaded: 678 -
Open Access Original Article
Standardized protocol proposed for clinical use of L-PRF and the use of L-PRF Wound Box®
Alessandro Crisci, ... Michela CrisciAim: The hypothesis is that the production of leukocyte and platelet-rich fibrin (L-PRF) is easy in horses without modifying human protocol, thus allowing better standardization of human protocol. In this study, the aim is to standardize the production of L-PRF in horses to direct it to human... Read More >J Unexplored Med Data 2017;2:77-87.Published on: 22 Nov 2017 Viewed: 5221 Downloaded: 484 -
Open Access Original Article
Epicatechin acts synergistically with curcumin-induced cytogenotoxic effect in acute promyelocytic leukemia HL-60 cell line
Monika A. Papież, Wirginia KrzyściakAim: The low bioavailability of curcumin, a polyphenol, limits its use as an antitumor agent. Identifying mechanisms to improve the bioavailability and effectiveness of curcumin can modify utilization of other plant-derived phenolic compounds. This study was conducted with an aim to determine... Read More >J Unexplored Med Data 2017;2:52-9.Published on: 25 Oct 2017 Viewed: 2142 Downloaded: 416 -
Open Access Short Communication
Salivary carbonic anhydrase, pH and phosphate buffer concentrations as potential biomarkers of caries risk in children
Yasmine Makawi, ... Hala Mohye El-DinAim: Oral fluid represents a mirror of the body and saliva has the potential to be used in the detection and diagnosis of diseases. The present study aimed to investigate the potential of salivary carbonic anhydrase (CA), salivary pH and phosphate buffer concentration as biomarkers of dental... Read More >J Unexplored Med Data 2017;2:9-15.Published on: 9 Feb 2017 Viewed: 5204 Downloaded: 610 -
Open Access Review
Narcotics and breast surgery: a review of current literature
Melissa Hite, ... Andrea M. AbbottOpioid consumption in the United States is the highest of all nations, with 42,000 people dying from opioid overdose in 2016. Patients with breast cancer undergoing curative-intent surgery are particularly vulnerable to developing persistent opioid use. It is anticipated that postoperatively... Read More >This article belongs to the Special Issue Caring for patients with breast cancerJ Unexplored Med Data 2019;4:9.Published on: 18 Nov 2019 Viewed: 117 Downloaded: 58
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Open Access Review
Immunotherapy in head and neck tumors: new options in advanced disease and beyond
Nicole B. Quenelle, Carrie L. CostantiniThis article aims to review the role of immunotherapy in tumors of the head and neck, focusing primarily on US Food and Drug Administration (FDA) approved checkpoint inhibitors in squamous cell histology. The data showing superiority of checkpoint inhibitors over cytotoxic chemotherapy that led... Read More >This article belongs to the Special Issue Immunotherapy as a new hope against solid tumorsJ Unexplored Med Data 2018;3:7.Published on: 31 Aug 2018 Viewed: 10409 Downloaded: 502 -
Open Access Review
Immunotherapy in colon cancer: approaching to the future
Esther Una CidonColon cancer is still one of the most common neoplasias every year, although screening strategies have reduced its incidence. Unfortunately, the median survival in metastatic cases, not candidates to surgery, remains less than 3 years, far away from the expectations. A few years back, new... Read More >This article belongs to the Special Issue Immunotherapy as a new hope against solid tumorsJ Unexplored Med Data 2018;3:8.Published on: 17 Oct 2018 Viewed: 1963 Downloaded: 358 -
Open Access Original Article
Ductal carcinoma in situ in the elderly: what is the ideal treatment plan?
Cosette A. DeChant, ... Jennifer K. PlichtaAim: To evaluate the association between local-regional treatment strategies on overall survival (OS), we compared elderly patients with ductal carcinoma in situ (DCIS) who underwent lumpectomy alone vs. lumpectomy + radiation or mastectomy. Methods: Patients ≥ 70 years in the National... Read More >This article belongs to the Special Issue Caring for patients with breast cancerJ Unexplored Med Data 2019;4:2.Published on: 27 Mar 2019 Viewed: 1073 Downloaded: 147 -
Open Access Original Article
Reasons symptomatic breast cancer patients delay seeking medical care
Jacqueline Heath, ... Rena KassAim: To assess for factors contributing to the total delay in care, and specifically the behavioral delay-interval portion of that delay, experienced by a group of symptomatic breast cancer patients. Methods: This retrospective cohort pilot study included 24 females greater than 40... Read More >This article belongs to the Special Issue Caring for patients with breast cancerJ Unexplored Med Data 2019;4:3.Published on: 30 Apr 2019 Viewed: 1035 Downloaded: 140 -
Open Access Review
Platelet-derived vesicles: diagnostic and predictive value in cardiovascular diseases
Alexander E. Berezin, Alexander A. BerezinThere is emerging evidence that endogenous microvesicles released by platelets may play a pivotal role in pathogenesis of numerous diseases including stable and unstable ischemic heart disease, atherosclerosis, hypertension, idiopathic pulmonary hypertension, atrial fibrillation/flutter, acute... Read More >This article belongs to the Special Issue New frontiers in platelet functionJ Unexplored Med Data 2019;4:4.Published on: 15 May 2019 Viewed: 1094 Downloaded: 145 -
Open Access Review
Lymphedema after treatment of breast cancer: a comprehensive review
Kareen Ayre, Catherine ParkerLymphedema is a chronic and morbid complication that can result from breast cancer treatment involving surgery and/or radiation therapy. Breast cancer related lymphedema (BCRL) can result in functional and psychological problems that can affect a patient’s quality of life. Lymphedema is a... Read More >This article belongs to the Special Issue Caring for patients with breast cancerJ Unexplored Med Data 2019;4:5.Published on: 13 Jun 2019 Viewed: 1239 Downloaded: 124
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Journal of Unexplored Medical Data is published by OAE Publishing Inc.