Most Viewed: Last TWO YEARS
  • Original Article|Open Access

    Safety and efficacy of biweekly cetuximab based chemotherapy for patients with metastatic colorectal cancer

    Jamal Zekri , Kamel Farag , Rawan Al-Saadi , Majed Ashour , Rasha Haggag
    Aim: Cetuximab was administered weekly in registration clinical trials. Biweekly administration is more convenient when combining cetuximab with biweekly chemotherapy in patients with metastatic colorectal cancer (mCRC). The aim of this study is to evaluate safety and efficacy of biweekly cetuximab at a dose of 500 mg/m2 with chemotherapy in routine clinical practice. Methods: Clinical data of 19 consecutive patients with K-RAS wild type mCRC who received biweekly cetuximab with biweekly fluropyrimidine based chemotherapy were reviewed. Toxicity assessment was limited to the first 6 cycles... Read more
    J Unexplored Med Data 2016;1:15-20. | doi:10.20517/2572-8180.2016.02
    Published on: 13 Sep 2016  | Viewed:33515  | Downloaded:843
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  • Original Article|Open Access

    In vivo anticancer efficacy assessment with an imaging-based platform: taking Brucea Javanica oil emulsion as an example

    Ye-Wei Liu , Ting Yin , Yuan-Bo Feng , Feng Chen , Jie Yu , Jian-Jun Liu , Shao-Li Song , Uwe Himmelreich , Raymond Oyen , Gang Huang , Yi-Cheng Ni
    Aim: Brucea Javanica oil emulsion (BJOE) has already been commercialized to treat various malignancies. The authors verified BJOE for its therapeutic effects on rhabdomyosarcoma (R1) in rats using magnetic resonance imaging (MRI), microangiography and histopathology. Methods: Rats were implanted with R1 in both flanks and subjected to intratumoral injections of BJOE or normal saline on day 0 and 7 for intra-individual comparisons. Therapeutic responses were compared between treated and control tumors at a 3.0 T MRI on day 0, 7 and 14 using T2-, T1-, and diffusionweighted imaging that... Read more
    J Unexplored Med Data 2016;1:21-9. | doi:10.20517/2572-8180.2016.04
    Published on: 13 Sep 2016  | Viewed:32546  | Downloaded:174
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  • Review|Open Access

    Surgical outcomes of distal splenorenal shunt or liver transplantation in treatment of schistosomal refractory variceal bleeding

    Wael Mohialddin Ahmed Doush , Juhaina Ahmed Elzein
    Schistosomiasis is one of the most prevalent neglected tropical diseases, remains a serious public health problem in many developing countries in the tropics and subtropics and its pathogenesis depends on the parasite-host interaction. Periportal fibrosis of schistosomiasis complicated by portal hypertension results from increased intrahepatic vascular resistance and blood flow through the portal venous system. This leads to portosystemic collateral variceal veins formation which dilates until they finally rupture and bleed due to progressive rising in the portal venous pressure. The... Read more
    J Unexplored Med Data 2018;3:2. | doi:10.20517/2572-8180.2017.18
    Published on: 30 Jan 2018  | Viewed:4839  | Downloaded:60
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  • Original Article|Open Access

    Knowledge, awareness, and practice of forensic odontology among dental surgeons in Bhubaneswar, India

    Juber Rahman , Samapika Routray , Sudhanshu S. Mishra , Ipsita Mohanty , Neeta Mohanty , Narayan Sukla
    Aim: The aim of the study was to evaluate knowledge, awareness, and practice related to forensic odontology among dental surgeons in Bhubaneswar, East India. Methods: A blind cross-sectional study, using a questionnaire with close-ended questions, was carried out. Interns were included to assess their knowledge and practice (related to dental record keeping) while in an institutional setting. In addition, dentists with Bachelor of Dental Surgery (BDS) and Master of Dental Surgery (MDS) qualifications (irrespective of their specialty) were assessed, which included purely private... Read more
    J Unexplored Med Data 2017;2:26-33. | doi:10.20517/2572-8180.2017.01
    Published on: 21 May 2017  | Viewed:4256  | Downloaded:211
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  • Original Article|Open Access

    Hormone naïve metastatic prostate cancer: can results of meta-analyses of aggregate data convince oncologists to expand the role of docetaxel?

    Jamal Zekri , Imran Ahmad , Saba Imtiaz
    Aim: Results of trial investigating addition of docetaxel (D) to androgen deprivation therapy (ADT) in patients with hormone naïve metastatic prostate cancer have been inconsistent. Thus meta-analysis is expected to settle the controversy. Methods: In this report, the authors highlight the results of randomized phase III trials and the results of recently published aggregated data meta-analysis (ADM) performed by the same investigators of these trials. In addition, the authors present and discuss the results of their own independent ADM. Three randomized phase III trials were identified.... Read more
    J Unexplored Med Data 2016;1:30-4. | doi:10.20517/2572-8180.2016.05
    Published on: 13 Sep 2016  | Viewed:3707  | Downloaded:271
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  • Short Communication|Open Access

    Relationship between family function and low back pain in nurses working in a tertiary hospital in North Central Nigeria

    Olawumi Olamide Iyaoromi , Musa Dankyau , Aboi Jeremiah Kutak Madaki
    Aim: The study aimed to determine the relationship between family functioning and low back pain (LBP) in nurses in a tertiary hospital in North Central Nigeria. Methods: A cross-sectional study using structured questionnaires was done among 204 randomly selected, eligible, consenting nurses in a tertiary hospital between August-November 2011. Sociodemographic data and Family APGAR Scores were collected, collated and analyzed with SPSS version 21. Results: Results showed that 92.2% (188) were from high functioning families, while 7.8% had moderately dysfunctional families. None of the... Read more
    J Unexplored Med Data 2017;2:16-9. | doi:10.20517/2572-8180.2016.09
    Published on: 13 Feb 2017  | Viewed:3268  | Downloaded:235
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  • Minireview|Open Access

    Treatment of epidermal growth factor receptor mutations in non-small cell lung cancer: current role and the future perspective

    Yasar Ahmed , Harliana Yousif
    Managing advanced non-small cell lung cancer has become far more complex than in the past. This in part is due to the fact that advances in molecular oncology allow for far more refined and effective treatment options for many lung cancer patients. One of the first advances was the identification of various biomarkers that are increasingly being tested for, even as a broad panel, that include some targets that we have been hearing about for a few years and others that are still emerging. Some of the most common biomarkers include epidermal growth factor receptor (EGFR) as well as anaplastic... Read more
    J Unexplored Med Data 2017;2:39-47. | doi:10.20517/2572-8180.2017.03
    Published on: 6 Jul 2017  | Viewed:3140  | Downloaded:215
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  • Original Article|Open Access

    Molecular characterization of cancer-associated fibroblasts isolated from human colorectal cancer as a major stromal cell component promoting metastasis

    Pravin D. Potdar , Shahid Chaudhary
    Aim: Colorectal cancer (CRC) remains a disease with poor prognosis and limited overall 5-year survival rate, which highlights a clear clinical need for novel treatment strategies. The stromal cancer-associated fibroblasts (CAFs) strongly dictate the metastatic potential of CRC and hence warrant investigation for clinical outcome. Methods: The authors established primary cultures of CAFs from metastatic CRC patients and performed cellular characterization using phase contrast microscopy and histological staining followed by light microscopy. The isolated CAFs were further explored for the... Read more
    J Unexplored Med Data 2017;2:1-8. | doi:10.20517/2572-8180.2016.10
    Published on: 9 Feb 2017  | Viewed:2950  | Downloaded:246
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  • Short Communication|Open Access

    Salivary carbonic anhydrase, pH and phosphate buffer concentrations as potential biomarkers of caries risk in children

    Yasmine Makawi , Eman El-Masry , Hala Mohye El-Din
    Aim: Oral fluid represents a mirror of the body and saliva has the potential to be used in the detection and diagnosis of diseases. The present study aimed to investigate the potential of salivary carbonic anhydrase (CA), salivary pH and phosphate buffer concentration as biomarkers of dental caries in children saliva. Methods: The study included 120 children of 3-5 years and 13-15 years of age group. Each age group was divided into two subgroups according to risk of dental caries: low and high caries risk groups. Two saliva samples, stimulated and non-stimulated, were collected from each... Read more
    J Unexplored Med Data 2017;2:9-15. | doi:10.20517/2572-8180.2016.07
    Published on: 9 Feb 2017  | Viewed:2808  | Downloaded:256
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  • Original Article|Open Access

    Association between tumor response and postoperative morbidity after neoadjuvant chemotherapy for gastroesophageal adenocarcinoma?

    Ulrich Ronellenfitsch , Eirini Liodaki , Marcus J. Trunk , Miriam Hahn , Emmanouil Liodakis , Ralf-Dieter Hofheinz , Stefan Post , Peter Kienle
    Aim: The recommended treatment for locally advanced gastroesophageal adenocarcinoma has changed to a multimodal approach including neoadjuvant chemotherapy. The aim of this study was to assess potential associations between response to neoadjuvant therapy and post-operative morbidity in patients with gastroesophageal adenocarcinoma. Methods: Sixty-one patients undergoing surgical resection of gastroesophageal adenocarcinoma following neoadjuvant chemotherapy were analyzed. Patients were dichotomized into histopathological responders (Becker grade Ia-II, n = 37) and nonresponders(Becker... Read more
    J Unexplored Med Data 2016;1:6-14. | doi:10.20517/2572-8180.2016.01
    Published on: 13 Sep 2016  | Viewed:2353  | Downloaded:147
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  • Case Report|Open Access

    Benign leiomyoma metastasizing to the lung: a case report and a brief review of the literature

    Grazia Lazzari , Francesco Perri , Giuseppina della Vittoria Scarpati , Salvatore Pisconti , Giovanni Silvano
    The authors have investigated a rare clinical condition consisting of a benign metastatic leiomyoma (BML) spreading in the lung, in a young woman. A 42-year-old woman affected by multiple pulmonary nodules histologically diagnosed as metastases from uterine sarcoma (one of them has been resected in the past and a pathologic diagnosis of uterine leyomiosarcoma was done) in concomitance with uterine bleeding, was referred to the Radiation Oncology Department of Taranto (Italy) Hospital, with the aim to perform an hemostatic radiotherapy after 4 cycles of induction chemotherapy. The patients... Read more
    J Unexplored Med Data 2017;2:34-8. | doi:10.20517/2572-8180.2017.06
    Published on: 14 Jun 2017  | Viewed:2201  | Downloaded:109
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  • Case Report|Open Access

    Crouzon syndrome: an experience of surgical intervention at Bangabandhu Sheikh Mujib Medical University, Bangladesh

    Jesmeen Morshed , Mahbub Mutanabbi , Md. Golam Hafiz
    Crouzon syndrome, also called craniofacial dysostosis is a rare autosomal dominant disease. It has a prevalence of 1 in 25,000 live births and it constitutes 4.8% of all craniosynostosis. Craniosynostosis, shallow orbits, maxillary hypoplasia, ocular proptosis and hypertelorism are the cardinal features of Crouzon syndrome. Here, the authors report a case of this rare entity who presented with brachycephaly, maxillary hypoplasia, shallow orbit, hypertelorism and bilateral proptosis. This patient’s overall management was done with the involvement of a multidisciplinary team. Read more
    J Unexplored Med Data 2017;2:48-51. | doi:10.20517/2572-8180.2017.05
    Published on: 29 Aug 2017  | Viewed:2005  | Downloaded:103
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  • Short Communication|Open Access

    Spike discharge prediction based on neuro-fuzzy system

    Mahdi Zarei
    This paper presents the development and evaluation of different versions of neuro-fuzzy model for prediction of spike discharge patterns. The author aims to predict the spike discharge variation using first spike latency and frequency-following interval. In order to study the spike discharge dynamics, the author analyzed the cerebral cortex data of the cat. Adaptive neuro-fuzzy inference systems (ANFIS), Wang and Mendel, dynamic evolving neural-fuzzy inference system, hybrid neural fuzzy inference system, genetic for lateral tuning and rule selection of linguistic fuzzy system (GFS.LT.RS)... Read more
    J Unexplored Med Data 2017;2:88-101. | doi:10.20517/2572-8180.2017.16
    Published on: 29 Nov 2017  | Viewed:1908  | Downloaded:45
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  • Case Report|Open Access

    A rare case of delayed chronic pneumonitis following non-medical grade silicone injections in a transgender woman

    Srilekha Sridhara , Mizba Baksh , Khatja Batool , Juel Chowdhury , Vijay Reddy , Stephanie Norwood , Sivaraman Sivaswami
    We describe a 47-year-old transgender woman with a history of non-medical grade silicone injections given by unauthorized persons 15-20 years prior to presentation who developed interstitial pneumonitis. She suffered acute exacerbations of pneumonitis, developed pulmonary fibrosis with terminal lung disease, acute respiratory distress syndrome and ventilator dependence and died of her illness. In light of the increasing awareness of the health concerns of the transgender population, we review here in the acute and chronic effects of silicone on the lung. Read more
    J Unexplored Med Data 2018;3:1. | doi:10.20517/2572-8180.2017.20
    Published on: 18 Jan 2018  | Viewed:1876  | Downloaded:57
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  • Editorial|Open Access

    Enteral immunonutrition in gastric cancer

    Xu Tian , Guo-Min Song , Qi Li
    J Unexplored Med Data 2016;1:3-5. | doi:10.20517/2572-8180.2016.03
    Published on: 13 Sep 2016  | Viewed:1756  | Downloaded:175
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  • Technical Note|Open Access

    Development and applications of acquisition techniques for rat pancreatic imaging at clinical scanners

    Ting Yin , Ronald Peeters , Jie Yu , Yicheng Ni
    Rat models are frequently used in preclinical studies on the pancreatic diseases. However, non-invasive imaging of rat pancreatic models has been hampered by the small size of the pancreas and the unpredictable motion artifacts in rat abdomen. Being widely accessible and of translational advantages, clinical magnetic resonance imaging (MRI) scanners have shown a great potential for small animal imaging studies. In this overview article, by combining clinically available hardware and imaging protocols, different technical challenges for rat pancreatic imaging on clinical MRI settings are... Read more
    J Unexplored Med Data 2017;2:65-76. | doi:10.20517/2572-8180.2017.19
    Published on: 14 Nov 2017  | Viewed:1660  | Downloaded:54
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  • Original Article|Open Access

    Standardized protocol proposed for clinical use of L-PRF and the use of L-PRF Wound Box®

    Alessandro Crisci , Domenico Lombardi , Edda Serra , Guido Lombardi , Federica Cardillo , Michela Crisci
    Aim: The hypothesis is that the production of leukocyte and platelet-rich fibrin (L-PRF) is easy in horses without modifying human protocol, thus allowing better standardization of human protocol. In this study, the aim is to standardize the production of L-PRF in horses to direct it to human production. Methods: The authors took 9 mL of blood from the jugular vein of 6 horses to produce L-PRF membranes at a temperature > 21 °C by measuring the size of the membranes (height, length, thickness, weight, surface) and clot. Therefore we analyzed their microbiological characteristics.... Read more
    J Unexplored Med Data 2017;2:77-87. | doi:10.20517/2572-8180.2017.17
    Published on: 22 Nov 2017  | Viewed:1462  | Downloaded:76
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  • Case Report|Open Access

    Metastatic renal medullary carcinoma: response to chemotherapy and unusual long survival

    Saba Imtiaz , Jamal Zekri
    Renal medullary carcinoma (RMC) is uncommon yet an aggressive form of renal cancer. Most patients present with metastatic disease. Systemic therapies recommended for clear cell carcinomas have not been well investigated for RMC. This report illustrates a case of a young female diagnosed with metastatic RMC and treated with 4 lines of systemic therapy. She remains alive and maintaining excellent quality of life more than 3 years after start of systemic therapy. Read more
    J Unexplored Med Data 2017;2:105-9. | doi:10.20517/2572-8180.2017.23
    Published on: 25 Dec 2017  | Viewed:1382  | Downloaded:89
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  • Editorial|Open Access

    Introduction to the first issue of JUMD

    Tarek Shalaby
    J Unexplored Med Data 2016;1:1-2. | doi:10.20517/2572-8180.2016.12
    Published on: 13 Sep 2016  | Viewed:1335  | Downloaded:119
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  • Short Communication|Open Access

    Endoscopic dual versus monotherapy in patients bleeding from high-risk peptic ulcers

    Angelo Andriulli , Silvano Loperfido , Grazia Napolitano , Rosaria Focareta , Fabio Fornari , Antonietta Garripoli , Antonio Merla , Antonio Massimo Ippolito , Pietro Leo , Riccardo Marmo
    Aim: Dual endoscopic and pharmacologic therapy is currently the standard treatment for patients with high-risk peptic ulcer bleeding. The authors assess the efficacy of dual (endoscopic and pharmacologic) therapy versus endoscopic monotherapy in reducing rates of recurrent bleeding and death in patients with high-risk peptic bleeds. Methods: The authors carried out a post-hoc analysis of data on the use of intravenous proton pump inhibitors for the prevention of rebleeding ulcers and death (from an investigator-supported multicenter randomized trial in Italy). All the patients bleeding from... Read more
    J Unexplored Med Data 2017;2:20-5. | doi:10.20517/2572-8180.2016.11
    Published on: 30 Mar 2017  | Viewed:1233  | Downloaded:120
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  • Review|Open Access

    Zebrafish as screening model for detecting toxicity and drugs efficacy

    Maria Virginia Caballero , Manila Candiracci
    Embryonic and larval Danio rerio is increasingly used as a toxicological model to conduct rapid in vivo tests and developmental toxicity assays; the zebrafish features as high genetic homology to mammals, robust phenotypes and its value in high-throughput genetic and chemical screening have made it a powerful tool to evaluate in vivo toxicity. New methodologies of genome editing as CRISPR/Cas9; ZFN or Talen make it a suitable model to perform studies to pair human genetic diseases as well. This review surveys recent studies employing zebrafish as experimental model, comparing it with other... Read more
    J Unexplored Med Data 2018;3:4. | doi:10.20517/2572-8180.2017.15
    Published on: 10 Feb 2018  | Viewed:1106  | Downloaded:87
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  • Original Article|Open Access

    Epicatechin acts synergistically with curcumin-induced cytogenotoxic effect in acute promyelocytic leukemia HL-60 cell line

    Monika A. Papież , Wirginia Krzyściak
    Aim: The low bioavailability of curcumin, a polyphenol, limits its use as an antitumor agent. Identifying mechanisms to improve the bioavailability and effectiveness of curcumin can modify utilization of other plant-derived phenolic compounds. This study was conducted with an aim to determine the influence of some flavonoids on the effects of curcumin in an HL-60 cell line. Methods: Cells were incubated in the presence of different concentrations of curcumin and several flavonoids for 20 h. Cytotoxicity was evaluated using propidium iodide staining. The evaluation of γH2AX expression using... Read more
    J Unexplored Med Data 2017;2:52-9. | doi:10.20517/2572-8180.2017.12
    Published on: 25 Oct 2017  | Viewed:954  | Downloaded:71
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  • Original Article|Open Access

    Cytotoxic effects of tamoxifen in breast cancer cells

    Firas Hassan , Ghufran Mohammed , Gamal A. El-Hiti , Ahemd Alshanon , Emad Yousif
    Aim: To investigate the cytotoxic effects of tamoxifen on the breast cancer cell line (MCF7). Methods: The cytotoxic effects of tamoxifen on MCF7 cells were investigated using caspase-9 activity and high content screening assays. Apoptosis mechanisms following tamoxifen treatment were also investigated. Results: The most significant cytotoxic effect of tamoxifen in MCF7 cells was a half-maximal inhibitory concentration (IC50) of 4.506 µg/mL. A significant increase in caspase-9 activity was also observed when MCF7 cells were treated with tamoxifen (5 µg/mL). Furthermore, increased cell... Read more
    J Unexplored Med Data 2018;3:3. | doi:10.20517/2572-8180.2017.25
    Published on: 9 Feb 2018  | Viewed:917  | Downloaded:78
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  • Editorial|Open Access

    Relationship between physicians and nurses in China: collaboration or subordination?

    Xu Tian , Xiao-Ling Liu , Yuan-Ping Pi , Wei-Qing Chen
    J Unexplored Med Data 2017;2:102-4. | doi:10.20517/2572-8180.2017.11
    Published on: 15 Dec 2017  | Viewed:743  | Downloaded:68
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  • Original Article|Open Access

    Analysis of resistant mutations in reverse transcriptase domain of hepatitis B virus from patients from Islamabad, Pakistan

    Majid Mahmood , Muhammad Asim Anwar
    Aim: To explore nucleoside/nucleotide analogues resistance mutations in hepatitis B virus (HBV) reverse transcriptase (RT) domain from non-responder Pakistani patients. Methods: Blood samples were taken from 20 chronic HBV patients who were non-responders to different nucleoside/nucleotide analogues. HBV DNA was extracted and a fragment of genome including RT domain was sequenced. The sequence was aligned with wild type HBV sequences and compared with resistant mutations in the RT domain. Results: Resistant mutations were detected in samples of 13 (65%) patients who were non-responders to... Read more
    J Unexplored Med Data 2017;2:60-4. | doi:10.20517/2572-8180.2017.13
    Published on: 31 Oct 2017  | Viewed:710  | Downloaded:75
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  • Editorial|Open Access

    2017 year in review

    Tarek Shalaby
    J Unexplored Med Data 2017;2:110-1. | doi:10.20517/2572-8180.2017.27
    Published on: 25 Dec 2017  | Viewed:632  | Downloaded:71
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  • Case Report|Open Access

    Unusual association of lupus and thrombotic thrombocytopenic purpura like syndrome: clinical experience of a rare presentation

    Mona Mahrous Abdellatif , Raghda Gabr Mashal
    Thrombotic thrombocytopenic purpura (TTP) is a life threatening hematological condition which can be secondary to many disorders. Systemic lupus erythematosus (SLE) can present with thrombotic microangiopathy and the differentiation between them is quiet difficult especially in people with no previous history of SLE. We report a case of 23-year-old female with no previous medical problems, who was presented with severe illness and dizziness following tooth extraction and was found to have severe microangiopathic hemolytic anemia, she was initially diagnosed as disseminated intravascular... Read more
    J Unexplored Med Data 2018;3:5. | doi:10.20517/2572-8180.2017.26
    Published on: 19 Apr 2018  | Viewed:141  | Downloaded:9
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Journal of Unexplored Medical Data Online ISSN: 2572-8180
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