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    Review| Open Access

    Immunotherapy in head and neck tumors: new options in advanced disease and beyond

    Nicole B. Quenelle, Carrie L. Costantini

    This article aims to review the role of immunotherapy in tumors of the head and neck, focusing primarily on US Food and Drug Administration (FDA) approved checkpoint inhibitors in squamous cell histology. The data showing superiority of checkpoint inhibitors over cytotoxic chemotherapy that led... Read more

    This article belongs to the Special Issue Immunotherapy as a new hope against solid tumors J Unexplored Med Data 2018;3:7. | doi:10.20517/2572-8180.2018.02
    Published on: 31 Aug 2018  | Viewed:209  | Downloaded:20
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    Original Article| Open Access

    Fabrication and evaluation of multiple pDNA-hydroxyapatite particles for transfection to HEK293 cells

    Rie Sasaki, Takayuki Takeshita, Masami Okamoto, Minoru Hirano, Katsunori Kohda

    Aim: This study aimed to assess multiple marker-loaded plasmid DNA (pDNA)-calcium phosphate (CaP) particles (pDNA-CaP) to allow multiple tumor drug delivery for therapy. Despite its widespread use as an in vitro pDNA-CaP transfection, little attention has been paid to multiple delivery systems.... Read more

    J Unexplored Med Data 2018;3:6. | doi:10.20517/2572-8180.2017.24
    Published on: 21 May 2018  | Viewed:798  | Downloaded:46
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    Case Report| Open Access

    Unusual association of lupus and thrombotic thrombocytopenic purpura like syndrome: clinical experience of a rare presentation

    Mona Mahrous Abdellatif, Raghda Gabr Mashal

    Thrombotic thrombocytopenic purpura (TTP) is a life threatening hematological condition which can be secondary to many disorders. Systemic lupus erythematosus (SLE) can present with thrombotic microangiopathy and the differentiation between them is quiet difficult especially in people with no... Read more

    J Unexplored Med Data 2018;3:5. | doi:10.20517/2572-8180.2017.26
    Published on: 19 Apr 2018  | Viewed:644  | Downloaded:28
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    Review| Open Access

    Zebrafish as screening model for detecting toxicity and drugs efficacy

    Maria Virginia Caballero, Manila Candiracci

    Embryonic and larval Danio rerio is increasingly used as a toxicological model to conduct rapid in vivo tests and developmental toxicity assays; the zebrafish features as high genetic homology to mammals, robust phenotypes and its value in high-throughput genetic and chemical screening have made... Read more

    J Unexplored Med Data 2018;3:4. | doi:10.20517/2572-8180.2017.15
    Published on: 10 Feb 2018  | Viewed:2506  | Downloaded:193
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    Original Article| Open Access

    Cytotoxic effects of tamoxifen in breast cancer cells

    Firas Hassan, Ghufran Mohammed, Gamal A. El-Hiti, Ahemd Alshanon, Emad Yousif

    Aim: To investigate the cytotoxic effects of tamoxifen on the breast cancer cell line (MCF7). Methods: The cytotoxic effects of tamoxifen on MCF7 cells were investigated using caspase-9 activity and high content screening assays. Apoptosis mechanisms following tamoxifen treatment were also... Read more

    J Unexplored Med Data 2018;3:3. | doi:10.20517/2572-8180.2017.25
    Published on: 9 Feb 2018  | Viewed:1809  | Downloaded:114
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    Review| Open Access

    Surgical outcomes of distal splenorenal shunt or liver transplantation in treatment of schistosomal refractory variceal bleeding

    Wael Mohialddin Ahmed Doush, Juhaina Ahmed Elzein

    Schistosomiasis is one of the most prevalent neglected tropical diseases, remains a serious public health problem in many developing countries in the tropics and subtropics and its pathogenesis depends on the parasite-host interaction. Periportal fibrosis of schistosomiasis complicated by portal... Read more

    J Unexplored Med Data 2018;3:2. | doi:10.20517/2572-8180.2017.18
    Published on: 30 Jan 2018  | Viewed:8975  | Downloaded:71
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    Case Report| Open Access

    A rare case of delayed chronic pneumonitis following non-medical grade silicone injections in a transgender woman

    Srilekha Sridhara, Mizba Baksh, Khatja Batool, Juel Chowdhury, Vijay Reddy, Stephanie Norwood, Sivaraman Sivaswami

    We describe a 47-year-old transgender woman with a history of non-medical grade silicone injections given by unauthorized persons 15-20 years prior to presentation who developed interstitial pneumonitis. She suffered acute exacerbations of pneumonitis, developed pulmonary fibrosis with terminal... Read more

    J Unexplored Med Data 2018;3:1. | doi:10.20517/2572-8180.2017.20
    Published on: 18 Jan 2018  | Viewed:3033  | Downloaded:71
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    Case Report| Open Access

    Metastatic renal medullary carcinoma: response to chemotherapy and unusual long survival

    Saba Imtiaz, Jamal Zekri

    Renal medullary carcinoma (RMC) is uncommon yet an aggressive form of renal cancer. Most patients present with metastatic disease. Systemic therapies recommended for clear cell carcinomas have not been well investigated for RMC. This report illustrates a case of a young female diagnosed with... Read more

    J Unexplored Med Data 2017;2:105-9. | doi:10.20517/2572-8180.2017.23
    Published on: 25 Dec 2017  | Viewed:1733  | Downloaded:105
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    Editorial| Open Access

    2017 year in review

    Tarek Shalaby J Unexplored Med Data 2017;2:110-1. | doi:10.20517/2572-8180.2017.27
    Published on: 25 Dec 2017  | Viewed:850  | Downloaded:89
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    Editorial| Open Access

    Relationship between physicians and nurses in China: collaboration or subordination?

    Xu Tian, Xiao-Ling Liu, Yuan-Ping Pi, Wei-Qing Chen J Unexplored Med Data 2017;2:102-4. | doi:10.20517/2572-8180.2017.11
    Published on: 15 Dec 2017  | Viewed:997  | Downloaded:82
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