• image 8 Mar 2018 Case Report| Open Access

    Steroids and plasma exchange in Isaacs' syndrome with anti-Caspr2 antibodies

    Daniele Orsucci , Gianfranco Cafforio , Gianluca Moscato , Alessandro Napolitano , Marco Margelli , Monica Mazzoni

    Isaacs’ syndrome is a disease characterized by nerve hyperexcitability. The patients are commonly treated with symptomatic therapies and immunomodulatory approaches, but no clinical trials are available to date. Here, we report the case of an anti-Caspr2-positive patient, presenting with...

    Neuroimmunology and Neuroinflammation [HTML] [PDF] Viewed:3232 Downloaded:40
  • image 1 Mar 2018 Review| Open Access

    Current challenges and opportunities in treating hypoxic prostate tumors

    Declan J. McKenna , Rachel Errington , Klaus Pors

    Hypoxia is a well-established characteristic of prostate tumors and is now recognised as a major contributory factor to both tumor progression and increased resistance to therapy. One strategy to target hypoxic tumor cells is the development of hypoxia-activated prodrugs (HAPs), which are...

    Journal of Cancer Metastasis and Treatment [HTML] [PDF] Viewed:724 Downloaded:62
  • image 27 Feb 2018 Technical Note| Open Access

    Safe and easy hair transplantation utilizing KD spreader

    Kuldeep Saxena

    Aim: An atraumatic insertion of graft is key to successful outcomes in this procedure but there is a definite learning curve in available techniques. Many physicians do not continue hair restoration practice because of the repeated initial failures. The goal of any technique or instrument in...

    Plastic and Aesthetic Research [HTML] [PDF] Viewed:557 Downloaded:56
  • image 27 Feb 2018 Review| Open Access

    Novel molecular players of X chromosome inactivation: new technologies and new insights

    Piotr Przanowski , Urszula Waśko , Sanchita Bhatnagar

    The dosage compensation in placental mammals is achieved by silencing of one copy of the X chromosomes in a female cell by a process called X chromosome inactivation (XCI). XCI ensures equal gene dosage for X-linked genes between the two genders. Although the choice of X chromosome to be silenced...

    Journal of Translational Genetics and Genomics [HTML] [PDF] Viewed:567 Downloaded:67
  • image 35976 Topic: Infectious Disease of Central Nervous System| Open Access

    Current diagnosis and treatment of cryptococcal meningitis without acquired immunodeficiency syndrome

    Xiao-Su Guo , Hui Bu , Jun-Ying He , Yue-Li Zou , Yue Zhao , Yuan-Yuan Li , Jun-Zhao Cui , Ming-Ming Zheng , Wei-Xin Han , Ze-Yan Zhao

    Cryptococcal meningitis (CM) is a central nervous system infectious disease caused by Cryptococcus. It is the most common fungal infection in the central nervous system, accounting for about 48% of fungal infection. The disease occurs mainly in acquired immunodeficiency syndrome (AIDS) patients...

    Neuroimmunology and Neuroinflammation [HTML] [PDF] Viewed:35976 Downloaded:320
  • image 232177 Review| Open Access

    Long non-coding RNAs as key regulators of cancer metastasis

    Pratirodh Koirala , De-Hong Zou , Yin-Yuan Mo

    The recent advances in functional genomics have discovered that a large number of long non-coding RNAs (lncRNAs) are pervasively transcribed from the human genome. Increasing evidence further indicates that lncRNAs are important for gene expression during cell differentiation and development...

    Journal of Cancer Metastasis and Treatment [HTML] [PDF] Viewed:232177 Downloaded:691
  • image 23128 Topic: Biomaterials for Plastic and Aesthetic Surgery| Open Access

    Intradermal fillers for minimally invasive treatment of facial aging

    Zhi Yuan (William) Lin , Vishva Shah , Arvind Dhinakar , Lara Yildirimer , Wen-Guo Cui , Xin Zhao

    The ever-increasing interest in retaining a youthful physical appearance has facilitated the development of various minimally invasive dermatological techniques. The use of intradermal fillers can be incorporated into dermatological practices with minimal overhead costs. This strategy addresses...

    Plastic and Aesthetic Research [HTML] [PDF] Viewed:23128 Downloaded:995
  • image 36122 Review| Open Access

    Hepatitis B virus molecular biology and pathogenesis

    R. Jason Lamontagne , Sumedha Bagga , Michael J. Bouchard

    As obligate intracellular parasites, viruses need a host cell to provide a milieu favorable to viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular signaling processes. While beneficial for the viral replication cycle, virus-induced deregulation of host...

    Hepatoma Research [HTML] [PDF] Viewed:36122 Downloaded:975
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