fig3

Figure 3. Non-invasive longitudinal follow up using 3D T2-weighted SPACE in a rat study on tumors, where an orthotopic pancreatic head tumor (thin arrow) was treated with a vascular disrupting agent CA4P. A: Intra-tumoral hemorrhage was presented as hypo-intense signal (thick arrow) after 7-h of CA4P injection, and hyper-intense necrosis core (thick arrow) was detected from SPACE images 24-h after treatment; B: corresponding MPR images clearly indicate the relationship between common bile duct and tumor, which is presented with volumetric rending. CA4P: combretastatin A4 phosphate; MPR: multiplanar reconstruction; K: kidney; arrowhead: common bile duct