Cover Picture: Brucea javanica (BJ) is a traditional Chinese herbal medicine that has been originally used to treat various ailments like amebic dysentery and malaria. In China, as a commercial therapeutic product , BJ oil emulsion (BJOE) has been commercialized to treat various malignancies including lung cancer, digestive tract cancers, prostate cancer and cervical cancer as well as their metastases. Research indicated that BJ exerts its anti-cancer effect by the active components in its seeds including quassinoids, triterpenoids, flavonolignan and flavonoids, pregnane glycosides and oleic and linoleic acid, etc. and mainly via the activation of caspase-dependent mitochondrial apoptotic pathway, and P53-, NF-kappa B-, COX-2-dependent death receptor pathways.
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