Topic: Negative results in pediatric CNS tumor research
A special issue of Journal of Unexplored Medical Data (Online ISSN：2572-8180).
Deadline for manuscript submissions: 30 Nov 2018
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- Tarek Shalaby, MD, PhD
- Senior researcher, formerly at the Department of Oncology, University Children's Hospital, 8008 Zurich, Switzerland.
Special Issue Introduction:
CNS tumors are a major cause of cancer-related morbidity and mortality in children. The journey of scientific research discovery including research into children's CNS tumors is subject to randomness and uncertainty. Most mainstream publishers reward scientists primarily for presenting positive findings, yet some of them may turn out to be unreproducible. When a study produces evidence that is inconsistent with the presumed hypothesis, it usually goes unreported and is not communicated to the scientific community.
There is a wealth of negative results in pediatric cancer research with useful information and learning experiences based on good, solid and expensive experimentation. Publishing such work will exploit novel opportunities for new hypothesis testing. Failure to publish null results while focusing exclusively on positive results in pediatric oncology may lead to false conclusions and publication bias. Best evidence-based medicine should include negative studies alongside the positive ones. Recognizing that null results are essential for the advancement of scientific thinking in children's CNS tumor research and acknowledging the potential value and the impact it can have on sharing such results within the academic community, JUMD is announcing the launch of a special issue to report negative results in pediatric CNS tumor research. Through this special issue, we want to encourage researchers to make their useful unpublished negative biomedical research data visible, shared and or cited. Let's make 2018 the year that biomedical negative results are unashamedly published.
Studies of interest in the field of CNS pediatric tumors include, but are not limited to:
▪ Studies reporting both positive and negative results;
▪ Experimental results that have not disproved the null hypothesis;
▪ Experimental results that didn't support your hypothesis;
▪ Experimental results - where the expected or desired effect was not observed;
▪ Research that failed to confirm the efficacy of therapeutic agents or procedures;
▪ Replication studies;
▪ Confirmatory and unconfirmatory studies.
Clinical trials, pilot studies, research reports, original articles, reviews and short communications.
Keywords: Pediatric brain tumors, children’s CNS cancer, primary brain tumors, secondary brain tumors
This special issue is now open for submission.
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