Topic: Immunotherapy as a new hope against solid tumors

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A special issue of Journal of Unexplored Medical Data  (Online ISSN:2572-8180).

Deadline for manuscript submissions: 30 Jun 2018

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Guest Editor(s)

  • Dr. Francesco Perri
    Department of Medical Oncology at the Hospital S.G. Moscati of Taranto, Italy.

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Special Issue Introduction:

The immune system is able to defend us against both pathogens and cancer.
Immune response against cancer cells is very complex, and it can be divided into three phases, such as: the innate immune response; the activation of specific T-cells against cancer and the killing of tumour cells made by the above mentioned T-cells.
On the basis of these findings, it is easy to understand that strengthen the immune response against tumour cells may be an incisive strategy of therapy.
Several immunotherapy approaches have been proposed over the years, however all of them have a common characteristic: the possibility to obtain a class of T-cytotoxic lymphocytes able to attack the tumor.
Immunotherapy strategies that have been developed over the years may be briefly divided in five categories: (1) direct administration of immunogenic tumour antigens; (2) providing DC pulsed with specific tumour antigens; (3) providing specific T-cells, pulsed with immunogenic tumour antigens; (4) administering cytokines able to activate T-cells against tumour cells; and (5) modifying the microenviromnent in which the T-cells mature, removing all the stimuli able to induce T-cells anergy.
The history of immunotherapy starts with the administration of prototypes of cancer vaccines, such as the Coley toxin and ends with the discover of the last generation checkpoint inhibitors.
Aim of our special issue is to review the importance and the clinical applications of several strategies of immunotherapy against solid tumors.

Keywords:

Immunotherapy, solid tumors

Submission Information:

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to http://jumdjournal.net/pages/view/author_instructions
For Online Submission, please login at http://jumdjournal.net/login
Submission Deadline: 30 Jun 2018
Contacts: Min Wan, Managing Editor, editorialoffice@jumdjournal.net

Published Articles Download All Articles
  • Immunotherapy in head and neck tumors: new options in advanced disease and beyond

    Nicole B. Quenelle , Carrie L. Costantini
    This article aims to review the role of immunotherapy in tumors of the head and neck, focusing primarily on US Food and Drug Administration (FDA) approved checkpoint inhibitors in squamous cell histology. The data showing superiority of checkpoint inhibitors over cytotoxic chemotherapy that led to FDA approval of two agents (Keytruda® Merck and Opdivo® Bristol-Myers-Squibb) in the recurrent and... Read more
    This article belongs to the Special Issue Immunotherapy as a new hope against solid tumors
    J Unexplored Med Data 2018;3:7. | doi:10.20517/2572-8180.2018.02
    Published on: 31 Aug 2018  | Viewed:442  | Downloaded:27
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Journal of Unexplored Medical Data ISSN 2572-8180 (Online)
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