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  • Original Article

    Safety and efficacy of biweekly cetuximab based chemotherapy for patients with metastatic colorectal cancer

    Jamal Zekri , Kamel Farag , Rawan Al-Saadi , Majed Ashour , Rasha Haggag
    Aim: Cetuximab was administered weekly in registration clinical trials. Biweekly administration is more convenient when combining cetuximab with biweekly chemotherapy in patients with metastatic colorectal cancer (mCRC). The aim of this study is to evaluate safety and efficacy of biweekly cetuximab at a dose of 500 mg/m2 with chemotherapy in routine clinical practice. Methods: Clinical data of 19 consecutive patients with K-RAS wild type mCRC who received biweekly cetuximab with biweekly fluropyrimidine based chemotherapy were reviewed. Toxicity assessment was limited to the first 6 cycles...
    Published on: 13 Sep 2016
    Views: 28466
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  • Original Article

    In vivo anticancer efficacy assessment with an imaging-based platform: taking Brucea Javanica oil emulsion as an example

    Ye-Wei Liu , Ting Yin , Yuan-Bo Feng , Feng Chen , Jie Yu , Jian-Jun Liu , Shao-Li Song , Uwe Himmelreich , Raymond Oyen , Gang Huang , Yi-Cheng Ni
    Aim: Brucea Javanica oil emulsion (BJOE) has already been commercialized to treat various malignancies. The authors verified BJOE for its therapeutic effects on rhabdomyosarcoma (R1) in rats using magnetic resonance imaging (MRI), microangiography and histopathology. Methods: Rats were implanted with R1 in both flanks and subjected to intratumoral injections of BJOE or normal saline on day 0 and 7 for intra-individual comparisons. Therapeutic responses were compared between treated and control tumors at a 3.0 T MRI on day 0, 7 and 14 using T2-, T1-, and diffusionweighted imaging that...
    Published on: 13 Sep 2016
    Views: 2416
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  • Original Article

    Hormone naïve metastatic prostate cancer: can results of meta-analyses of aggregate data convince oncologists to expand the role of docetaxel?

    Jamal Zekri , Imran Ahmad , Saba Imtiaz
    Aim: Results of trial investigating addition of docetaxel (D) to androgen deprivation therapy (ADT) in patients with hormone naïve metastatic prostate cancer have been inconsistent. Thus meta-analysis is expected to settle the controversy. Methods: In this report, the authors highlight the results of randomized phase III trials and the results of recently published aggregated data meta-analysis (ADM) performed by the same investigators of these trials. In addition, the authors present and discuss the results of their own independent ADM. Three randomized phase III trials were identified....
    Published on: 13 Sep 2016
    Views: 1398
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  • Original Article

    Association between tumor response and postoperative morbidity after neoadjuvant chemotherapy for gastroesophageal adenocarcinoma?

    Ulrich Ronellenfitsch , Eirini Liodaki , Marcus J. Trunk , Miriam Hahn , Emmanouil Liodakis , Ralf-Dieter Hofheinz , Stefan Post , Peter Kienle
    Aim: The recommended treatment for locally advanced gastroesophageal adenocarcinoma has changed to a multimodal approach including neoadjuvant chemotherapy. The aim of this study was to assess potential associations between response to neoadjuvant therapy and post-operative morbidity in patients with gastroesophageal adenocarcinoma. Methods: Sixty-one patients undergoing surgical resection of gastroesophageal adenocarcinoma following neoadjuvant chemotherapy were analyzed. Patients were dichotomized into histopathological responders (Becker grade Ia-II, n = 37) and nonresponders(Becker...
    Published on: 13 Sep 2016
    Views: 1045
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  • Editorial

    Enteral immunonutrition in gastric cancer

    Xu Tian , Guo-Min Song , Qi Li
    Published on: 13 Sep 2016
    Views: 813
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  • Original Article

    Molecular characterization of cancer-associated fibroblasts isolated from human colorectal cancer as a major stromal cell component promoting metastasis

    Pravin D. Potdar , Shahid Chaudhary
    Aim: Colorectal cancer (CRC) remains a disease with poor prognosis and limited overall 5-year survival rate, which highlights a clear clinical need for novel treatment strategies. The stromal cancer-associated fibroblasts (CAFs) strongly dictate the metastatic potential of CRC and hence warrant investigation for clinical outcome. Methods: The authors established primary cultures of CAFs from metastatic CRC patients and performed cellular characterization using phase contrast microscopy and histological staining followed by light microscopy. The isolated CAFs were further explored for the...
    Published on: 9 Feb 2017
    Views: 745
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  • Short Communication

    Relationship between family function and low back pain in nurses working in a tertiary hospital in North Central Nigeria

    Olawumi Olamide Iyaoromi , Musa Dankyau , Aboi Jeremiah Kutak Madaki
    Aim: The study aimed to determine the relationship between family functioning and low back pain (LBP) in nurses in a tertiary hospital in North Central Nigeria. Methods: A cross-sectional study using structured questionnaires was done among 204 randomly selected, eligible, consenting nurses in a tertiary hospital between August-November 2011. Sociodemographic data and Family APGAR Scores were collected, collated and analyzed with SPSS version 21. Results: Results showed that 92.2% (188) were from high functioning families, while 7.8% had moderately dysfunctional families. None of the...
    Published on: 13 Feb 2017
    Views: 562
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  • Short Communication

    Salivary carbonic anhydrase, pH and phosphate buffer concentrations as potential biomarkers of caries risk in children

    Yasmine Makawi , Eman El-Masry , Hala Mohye El-Din
    Aim: Oral fluid represents a mirror of the body and saliva has the potential to be used in the detection and diagnosis of diseases. The present study aimed to investigate the potential of salivary carbonic anhydrase (CA), salivary pH and phosphate buffer concentration as biomarkers of dental caries in children saliva. Methods: The study included 120 children of 3-5 years and 13-15 years of age group. Each age group was divided into two subgroups according to risk of dental caries: low and high caries risk groups. Two saliva samples, stimulated and non-stimulated, were collected from each...
    Published on: 9 Feb 2017
    Views: 558
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  • Editorial

    Introduction to the first issue of JUMD

    Tarek Shalaby
    Published on: 13 Sep 2016
    Views: 542
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  • Short Communication

    Endoscopic dual versus monotherapy in patients bleeding from high-risk peptic ulcers

    Angelo Andriulli , Silvano Loperfido , Grazia Napolitano , Rosaria Focareta , Fabio Fornari , Antonietta Garripoli , Antonio Merla , Antonio Massimo Ippolito , Pietro Leo , Riccardo Marmo
    Aim: Dual endoscopic and pharmacologic therapy is currently the standard treatment for patients with high-risk peptic ulcer bleeding. The authors assess the efficacy of dual (endoscopic and pharmacologic) therapy versus endoscopic monotherapy in reducing rates of recurrent bleeding and death in patients with high-risk peptic bleeds. Methods: The authors carried out a post-hoc analysis of data on the use of intravenous proton pump inhibitors for the prevention of rebleeding ulcers and death (from an investigator-supported multicenter randomized trial in Italy). All the patients bleeding from...
    Published on: 30 Mar 2017
    Views: 110
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  • Original Article

    Knowledge, awareness, and practice of forensic odontology among dental surgeons in Bhubaneswar, India

    Juber Rahman , Samapika Routray , Sudhanshu S. Mishra , Ipsita Mohanty , Neeta Mohanty , Narayan Sukla
    Aim: The aim of the study was to evaluate knowledge, awareness, and practice related to forensic odontology among dental surgeons in Bhubaneswar, East India. Methods: A blind cross-sectional study, using a questionnaire with close-ended questions, was carried out. Interns were included to assess their knowledge and practice (related to dental record keeping) while in an institutional setting. In addition, dentists with Bachelor of Dental Surgery (BDS) and Master of Dental Surgery (MDS) qualifications (irrespective of their specialty) were assessed, which included purely private...
    Published on: 21 May 2017
    Views: 9
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