Most Viewed: Last ONE YEAR
  • Original Article|Open Access

    Molecular characterization of cancer-associated fibroblasts isolated from human colorectal cancer as a major stromal cell component promoting metastasis

    Pravin D. Potdar , Shahid Chaudhary
    Aim: Colorectal cancer (CRC) remains a disease with poor prognosis and limited overall 5-year survival rate, which highlights a clear clinical need for novel treatment strategies. The stromal cancer-associated fibroblasts (CAFs) strongly dictate the metastatic potential of CRC and hence warrant investigation for clinical outcome. Methods: The authors established primary cultures of CAFs from metastatic CRC patients and performed cellular characterization using phase contrast microscopy and histological staining followed by light microscopy. The isolated CAFs were further explored for the... Read more
    J Unexplored Med Data 2017;2:1-8. | doi:10.20517/2572-8180.2016.10
    Published on: 9 Feb 2017  | Viewed:1555  | Downloaded:174
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  • Short Communication|Open Access

    Relationship between family function and low back pain in nurses working in a tertiary hospital in North Central Nigeria

    Olawumi Olamide Iyaoromi , Musa Dankyau , Aboi Jeremiah Kutak Madaki
    Aim: The study aimed to determine the relationship between family functioning and low back pain (LBP) in nurses in a tertiary hospital in North Central Nigeria. Methods: A cross-sectional study using structured questionnaires was done among 204 randomly selected, eligible, consenting nurses in a tertiary hospital between August-November 2011. Sociodemographic data and Family APGAR Scores were collected, collated and analyzed with SPSS version 21. Results: Results showed that 92.2% (188) were from high functioning families, while 7.8% had moderately dysfunctional families. None of the... Read more
    J Unexplored Med Data 2017;2:16-9. | doi:10.20517/2572-8180.2016.09
    Published on: 13 Feb 2017  | Viewed:1508  | Downloaded:179
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  • Original Article|Open Access

    Knowledge, awareness, and practice of forensic odontology among dental surgeons in Bhubaneswar, India

    Juber Rahman , Samapika Routray , Sudhanshu S. Mishra , Ipsita Mohanty , Neeta Mohanty , Narayan Sukla
    Aim: The aim of the study was to evaluate knowledge, awareness, and practice related to forensic odontology among dental surgeons in Bhubaneswar, East India. Methods: A blind cross-sectional study, using a questionnaire with close-ended questions, was carried out. Interns were included to assess their knowledge and practice (related to dental record keeping) while in an institutional setting. In addition, dentists with Bachelor of Dental Surgery (BDS) and Master of Dental Surgery (MDS) qualifications (irrespective of their specialty) were assessed, which included purely private... Read more
    J Unexplored Med Data 2017;2:26-33. | doi:10.20517/2572-8180.2017.01
    Published on: 21 May 2017  | Viewed:1368  | Downloaded:117
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  • Short Communication|Open Access

    Salivary carbonic anhydrase, pH and phosphate buffer concentrations as potential biomarkers of caries risk in children

    Yasmine Makawi , Eman El-Masry , Hala Mohye El-Din
    Aim: Oral fluid represents a mirror of the body and saliva has the potential to be used in the detection and diagnosis of diseases. The present study aimed to investigate the potential of salivary carbonic anhydrase (CA), salivary pH and phosphate buffer concentration as biomarkers of dental caries in children saliva. Methods: The study included 120 children of 3-5 years and 13-15 years of age group. Each age group was divided into two subgroups according to risk of dental caries: low and high caries risk groups. Two saliva samples, stimulated and non-stimulated, were collected from each... Read more
    J Unexplored Med Data 2017;2:9-15. | doi:10.20517/2572-8180.2016.07
    Published on: 9 Feb 2017  | Viewed:1231  | Downloaded:178
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  • Minireview|Open Access

    Treatment of epidermal growth factor receptor mutations in non-small cell lung cancer: current role and the future perspective

    Yasar Ahmed , Harliana Yousif
    Managing advanced non-small cell lung cancer has become far more complex than in the past. This in part is due to the fact that advances in molecular oncology allow for far more refined and effective treatment options for many lung cancer patients. One of the first advances was the identification of various biomarkers that are increasingly being tested for, even as a broad panel, that include some targets that we have been hearing about for a few years and others that are still emerging. Some of the most common biomarkers include epidermal growth factor receptor (EGFR) as well as anaplastic... Read more
    J Unexplored Med Data 2017;2:39-47. | doi:10.20517/2572-8180.2017.03
    Published on: 6 Jul 2017  | Viewed:1031  | Downloaded:133
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  • Case Report|Open Access

    Benign leiomyoma metastasizing to the lung: a case report and a brief review of the literature

    Grazia Lazzari , Francesco Perri , Giuseppina della Vittoria Scarpati , Salvatore Pisconti , Giovanni Silvano
    The authors have investigated a rare clinical condition consisting of a benign metastatic leiomyoma (BML) spreading in the lung, in a young woman. A 42-year-old woman affected by multiple pulmonary nodules histologically diagnosed as metastases from uterine sarcoma (one of them has been resected in the past and a pathologic diagnosis of uterine leyomiosarcoma was done) in concomitance with uterine bleeding, was referred to the Radiation Oncology Department of Taranto (Italy) Hospital, with the aim to perform an hemostatic radiotherapy after 4 cycles of induction chemotherapy. The patients... Read more
    J Unexplored Med Data 2017;2:34-8. | doi:10.20517/2572-8180.2017.06
    Published on: 14 Jun 2017  | Viewed:866  | Downloaded:62
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  • Short Communication|Open Access

    Endoscopic dual versus monotherapy in patients bleeding from high-risk peptic ulcers

    Angelo Andriulli , Silvano Loperfido , Grazia Napolitano , Rosaria Focareta , Fabio Fornari , Antonietta Garripoli , Antonio Merla , Antonio Massimo Ippolito , Pietro Leo , Riccardo Marmo
    Aim: Dual endoscopic and pharmacologic therapy is currently the standard treatment for patients with high-risk peptic ulcer bleeding. The authors assess the efficacy of dual (endoscopic and pharmacologic) therapy versus endoscopic monotherapy in reducing rates of recurrent bleeding and death in patients with high-risk peptic bleeds. Methods: The authors carried out a post-hoc analysis of data on the use of intravenous proton pump inhibitors for the prevention of rebleeding ulcers and death (from an investigator-supported multicenter randomized trial in Italy). All the patients bleeding from... Read more
    J Unexplored Med Data 2017;2:20-5. | doi:10.20517/2572-8180.2016.11
    Published on: 30 Mar 2017  | Viewed:512  | Downloaded:67
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  • Case Report|Open Access

    Crouzon syndrome: an experience of surgical intervention at Bangabandhu Sheikh Mujib Medical University, Bangladesh

    Jesmeen Morshed , Mahbub Mutanabbi , Md. Golam Hafiz
    Crouzon syndrome, also called craniofacial dysostosis is a rare autosomal dominant disease. It has a prevalence of 1 in 25,000 live births and it constitutes 4.8% of all craniosynostosis. Craniosynostosis, shallow orbits, maxillary hypoplasia, ocular proptosis and hypertelorism are the cardinal features of Crouzon syndrome. Here, the authors report a case of this rare entity who presented with brachycephaly, maxillary hypoplasia, shallow orbit, hypertelorism and bilateral proptosis. This patient’s overall management was done with the involvement of a multidisciplinary team. Read more
    J Unexplored Med Data 2017;2:48-51. | doi:10.20517/2572-8180.2017.05
    Published on: 29 Aug 2017  | Viewed:362  | Downloaded:36
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Journal of Unexplored Medical Data Online ISSN: 2572-8180
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