Latest
  • Review|Open Access

    Immunotherapy in head and neck tumors: new options in advanced disease and beyond

    Nicole B. Quenelle, Carrie L. Costantini
    This article aims to review the role of immunotherapy in tumors of the head and neck, focusing primarily on US Food and Drug Administration (FDA) approved checkpoint inhibitors in squamous cell histology. The data showing superiority of checkpoint inhibitors over cytotoxic chemotherapy that led to FDA approval of two agents (Keytruda® Merck and Opdivo® Bristol-Myers-Squibb) in the recurrent and metastatic setting will be reviewed in detail, as well as summaries of ongoing trials for checkpoint inhibitor and combination therapies in both the curative and metastatic settings. Upcoming... Read more
    This article belongs to the Special Issue Immunotherapy as a new hope against solid tumors
    J Unexplored Med Data 2018;3:7. | doi:10.20517/2572-8180.2018.02
    Published on: 31 Aug 2018  | Viewed:209  | Downloaded:20
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  • Original Article|Open Access

    Fabrication and evaluation of multiple pDNA-hydroxyapatite particles for transfection to HEK293 cells

    Rie Sasaki, Takayuki Takeshita, Masami Okamoto, Minoru Hirano, Katsunori Kohda
    Aim: This study aimed to assess multiple marker-loaded plasmid DNA (pDNA)-calcium phosphate (CaP) particles (pDNA-CaP) to allow multiple tumor drug delivery for therapy. Despite its widespread use as an in vitro pDNA-CaP transfection, little attention has been paid to multiple delivery systems. Methods: We optimized Ca:P ion ratios by varying ion concentrations in simulated body fluid solutions to induce sufficient protein expression. We examined the effect of the multiple marker-loaded pDNA-hydroxyapatite (HA) particles, including three markers of pDNA on the transfection to human... Read more
    J Unexplored Med Data 2018;3:6. | doi:10.20517/2572-8180.2017.24
    Published on: 21 May 2018  | Viewed:798  | Downloaded:46
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  • Case Report|Open Access

    Unusual association of lupus and thrombotic thrombocytopenic purpura like syndrome: clinical experience of a rare presentation

    Mona Mahrous Abdellatif, Raghda Gabr Mashal
    Thrombotic thrombocytopenic purpura (TTP) is a life threatening hematological condition which can be secondary to many disorders. Systemic lupus erythematosus (SLE) can present with thrombotic microangiopathy and the differentiation between them is quiet difficult especially in people with no previous history of SLE. We report a case of 23-year-old female with no previous medical problems, who was presented with severe illness and dizziness following tooth extraction and was found to have severe microangiopathic hemolytic anemia, she was initially diagnosed as disseminated intravascular... Read more
    J Unexplored Med Data 2018;3:5. | doi:10.20517/2572-8180.2017.26
    Published on: 19 Apr 2018  | Viewed:644  | Downloaded:28
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  • Review|Open Access

    Zebrafish as screening model for detecting toxicity and drugs efficacy

    Maria Virginia Caballero, Manila Candiracci
    Embryonic and larval Danio rerio is increasingly used as a toxicological model to conduct rapid in vivo tests and developmental toxicity assays; the zebrafish features as high genetic homology to mammals, robust phenotypes and its value in high-throughput genetic and chemical screening have made it a powerful tool to evaluate in vivo toxicity. New methodologies of genome editing as CRISPR/Cas9; ZFN or Talen make it a suitable model to perform studies to pair human genetic diseases as well. This review surveys recent studies employing zebrafish as experimental model, comparing it with other... Read more
    J Unexplored Med Data 2018;3:4. | doi:10.20517/2572-8180.2017.15
    Published on: 10 Feb 2018  | Viewed:2506  | Downloaded:193
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  • Original Article|Open Access

    Cytotoxic effects of tamoxifen in breast cancer cells

    Firas Hassan, Ghufran Mohammed, Gamal A. El-Hiti, Ahemd Alshanon, Emad Yousif
    Aim: To investigate the cytotoxic effects of tamoxifen on the breast cancer cell line (MCF7). Methods: The cytotoxic effects of tamoxifen on MCF7 cells were investigated using caspase-9 activity and high content screening assays. Apoptosis mechanisms following tamoxifen treatment were also investigated. Results: The most significant cytotoxic effect of tamoxifen in MCF7 cells was a half-maximal inhibitory concentration (IC50) of 4.506 µg/mL. A significant increase in caspase-9 activity was also observed when MCF7 cells were treated with tamoxifen (5 µg/mL). Furthermore, increased cell... Read more
    J Unexplored Med Data 2018;3:3. | doi:10.20517/2572-8180.2017.25
    Published on: 9 Feb 2018  | Viewed:1809  | Downloaded:114
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  • Review|Open Access

    Surgical outcomes of distal splenorenal shunt or liver transplantation in treatment of schistosomal refractory variceal bleeding

    Wael Mohialddin Ahmed Doush, Juhaina Ahmed Elzein
    Schistosomiasis is one of the most prevalent neglected tropical diseases, remains a serious public health problem in many developing countries in the tropics and subtropics and its pathogenesis depends on the parasite-host interaction. Periportal fibrosis of schistosomiasis complicated by portal hypertension results from increased intrahepatic vascular resistance and blood flow through the portal venous system. This leads to portosystemic collateral variceal veins formation which dilates until they finally rupture and bleed due to progressive rising in the portal venous pressure. The... Read more
    J Unexplored Med Data 2018;3:2. | doi:10.20517/2572-8180.2017.18
    Published on: 30 Jan 2018  | Viewed:8975  | Downloaded:71
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  • Case Report|Open Access

    A rare case of delayed chronic pneumonitis following non-medical grade silicone injections in a transgender woman

    Srilekha Sridhara, Mizba Baksh, Khatja Batool, Juel Chowdhury, Vijay Reddy, Stephanie Norwood, Sivaraman Sivaswami
    We describe a 47-year-old transgender woman with a history of non-medical grade silicone injections given by unauthorized persons 15-20 years prior to presentation who developed interstitial pneumonitis. She suffered acute exacerbations of pneumonitis, developed pulmonary fibrosis with terminal lung disease, acute respiratory distress syndrome and ventilator dependence and died of her illness. In light of the increasing awareness of the health concerns of the transgender population, we review here in the acute and chronic effects of silicone on the lung. Read more
    J Unexplored Med Data 2018;3:1. | doi:10.20517/2572-8180.2017.20
    Published on: 18 Jan 2018  | Viewed:3033  | Downloaded:71
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  • Case Report|Open Access

    Metastatic renal medullary carcinoma: response to chemotherapy and unusual long survival

    Saba Imtiaz, Jamal Zekri
    Renal medullary carcinoma (RMC) is uncommon yet an aggressive form of renal cancer. Most patients present with metastatic disease. Systemic therapies recommended for clear cell carcinomas have not been well investigated for RMC. This report illustrates a case of a young female diagnosed with metastatic RMC and treated with 4 lines of systemic therapy. She remains alive and maintaining excellent quality of life more than 3 years after start of systemic therapy. Read more
    J Unexplored Med Data 2017;2:105-9. | doi:10.20517/2572-8180.2017.23
    Published on: 25 Dec 2017  | Viewed:1733  | Downloaded:105
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  • Editorial|Open Access

    2017 year in review

    Tarek Shalaby
    J Unexplored Med Data 2017;2:110-1. | doi:10.20517/2572-8180.2017.27
    Published on: 25 Dec 2017  | Viewed:850  | Downloaded:89
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  • Editorial|Open Access

    Relationship between physicians and nurses in China: collaboration or subordination?

    Xu Tian, Xiao-Ling Liu, Yuan-Ping Pi, Wei-Qing Chen
    J Unexplored Med Data 2017;2:102-4. | doi:10.20517/2572-8180.2017.11
    Published on: 15 Dec 2017  | Viewed:997  | Downloaded:82
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  • Short Communication|Open Access

    Spike discharge prediction based on neuro-fuzzy system

    Mahdi Zarei
    This paper presents the development and evaluation of different versions of neuro-fuzzy model for prediction of spike discharge patterns. The author aims to predict the spike discharge variation using first spike latency and frequency-following interval. In order to study the spike discharge dynamics, the author analyzed the cerebral cortex data of the cat. Adaptive neuro-fuzzy inference systems (ANFIS), Wang and Mendel, dynamic evolving neural-fuzzy inference system, hybrid neural fuzzy inference system, genetic for lateral tuning and rule selection of linguistic fuzzy system (GFS.LT.RS)... Read more
    J Unexplored Med Data 2017;2:88-101. | doi:10.20517/2572-8180.2017.16
    Published on: 29 Nov 2017  | Viewed:2448  | Downloaded:48
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  • Original Article|Open Access

    Standardized protocol proposed for clinical use of L-PRF and the use of L-PRF Wound Box®

    Alessandro Crisci, Domenico Lombardi, Edda Serra, Guido Lombardi, Federica Cardillo, Michela Crisci
    Aim: The hypothesis is that the production of leukocyte and platelet-rich fibrin (L-PRF) is easy in horses without modifying human protocol, thus allowing better standardization of human protocol. In this study, the aim is to standardize the production of L-PRF in horses to direct it to human production. Methods: The authors took 9 mL of blood from the jugular vein of 6 horses to produce L-PRF membranes at a temperature > 21 °C by measuring the size of the membranes (height, length, thickness, weight, surface) and clot. Therefore we analyzed their microbiological characteristics.... Read more
    J Unexplored Med Data 2017;2:77-87. | doi:10.20517/2572-8180.2017.17
    Published on: 22 Nov 2017  | Viewed:2240  | Downloaded:93
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  • Technical Note|Open Access

    Development and applications of acquisition techniques for rat pancreatic imaging at clinical scanners

    Ting Yin, Ronald Peeters, Jie Yu, Yicheng Ni
    Rat models are frequently used in preclinical studies on the pancreatic diseases. However, non-invasive imaging of rat pancreatic models has been hampered by the small size of the pancreas and the unpredictable motion artifacts in rat abdomen. Being widely accessible and of translational advantages, clinical magnetic resonance imaging (MRI) scanners have shown a great potential for small animal imaging studies. In this overview article, by combining clinically available hardware and imaging protocols, different technical challenges for rat pancreatic imaging on clinical MRI settings are... Read more
    J Unexplored Med Data 2017;2:65-76. | doi:10.20517/2572-8180.2017.19
    Published on: 14 Nov 2017  | Viewed:2472  | Downloaded:63
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  • Original Article|Open Access

    Analysis of resistant mutations in reverse transcriptase domain of hepatitis B virus from patients from Islamabad, Pakistan

    Majid Mahmood, Muhammad Asim Anwar
    Aim: To explore nucleoside/nucleotide analogues resistance mutations in hepatitis B virus (HBV) reverse transcriptase (RT) domain from non-responder Pakistani patients. Methods: Blood samples were taken from 20 chronic HBV patients who were non-responders to different nucleoside/nucleotide analogues. HBV DNA was extracted and a fragment of genome including RT domain was sequenced. The sequence was aligned with wild type HBV sequences and compared with resistant mutations in the RT domain. Results: Resistant mutations were detected in samples of 13 (65%) patients who were non-responders to... Read more
    J Unexplored Med Data 2017;2:60-4. | doi:10.20517/2572-8180.2017.13
    Published on: 31 Oct 2017  | Viewed:890  | Downloaded:86
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  • Original Article|Open Access

    Epicatechin acts synergistically with curcumin-induced cytogenotoxic effect in acute promyelocytic leukemia HL-60 cell line

    Monika A. Papież, Wirginia Krzyściak
    Aim: The low bioavailability of curcumin, a polyphenol, limits its use as an antitumor agent. Identifying mechanisms to improve the bioavailability and effectiveness of curcumin can modify utilization of other plant-derived phenolic compounds. This study was conducted with an aim to determine the influence of some flavonoids on the effects of curcumin in an HL-60 cell line. Methods: Cells were incubated in the presence of different concentrations of curcumin and several flavonoids for 20 h. Cytotoxicity was evaluated using propidium iodide staining. The evaluation of γH2AX expression using... Read more
    J Unexplored Med Data 2017;2:52-9. | doi:10.20517/2572-8180.2017.12
    Published on: 25 Oct 2017  | Viewed:1331  | Downloaded:84
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  • Case Report|Open Access

    Crouzon syndrome: an experience of surgical intervention at Bangabandhu Sheikh Mujib Medical University, Bangladesh

    Jesmeen Morshed, Mahbub Mutanabbi, Md. Golam Hafiz
    Crouzon syndrome, also called craniofacial dysostosis is a rare autosomal dominant disease. It has a prevalence of 1 in 25,000 live births and it constitutes 4.8% of all craniosynostosis. Craniosynostosis, shallow orbits, maxillary hypoplasia, ocular proptosis and hypertelorism are the cardinal features of Crouzon syndrome. Here, the authors report a case of this rare entity who presented with brachycephaly, maxillary hypoplasia, shallow orbit, hypertelorism and bilateral proptosis. This patient’s overall management was done with the involvement of a multidisciplinary team. Read more
    J Unexplored Med Data 2017;2:48-51. | doi:10.20517/2572-8180.2017.05
    Published on: 29 Aug 2017  | Viewed:2738  | Downloaded:130
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  • Minireview|Open Access

    Treatment of epidermal growth factor receptor mutations in non-small cell lung cancer: current role and the future perspective

    Yasar Ahmed, Harliana Yousif
    Managing advanced non-small cell lung cancer has become far more complex than in the past. This in part is due to the fact that advances in molecular oncology allow for far more refined and effective treatment options for many lung cancer patients. One of the first advances was the identification of various biomarkers that are increasingly being tested for, even as a broad panel, that include some targets that we have been hearing about for a few years and others that are still emerging. Some of the most common biomarkers include epidermal growth factor receptor (EGFR) as well as anaplastic... Read more
    J Unexplored Med Data 2017;2:39-47. | doi:10.20517/2572-8180.2017.03
    Published on: 6 Jul 2017  | Viewed:4225  | Downloaded:265
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  • Case Report|Open Access

    Benign leiomyoma metastasizing to the lung: a case report and a brief review of the literature

    Grazia Lazzari, Francesco Perri, Giuseppina della Vittoria Scarpati, Salvatore Pisconti, Giovanni Silvano
    The authors have investigated a rare clinical condition consisting of a benign metastatic leiomyoma (BML) spreading in the lung, in a young woman. A 42-year-old woman affected by multiple pulmonary nodules histologically diagnosed as metastases from uterine sarcoma (one of them has been resected in the past and a pathologic diagnosis of uterine leyomiosarcoma was done) in concomitance with uterine bleeding, was referred to the Radiation Oncology Department of Taranto (Italy) Hospital, with the aim to perform an hemostatic radiotherapy after 4 cycles of induction chemotherapy. The patients... Read more
    J Unexplored Med Data 2017;2:34-8. | doi:10.20517/2572-8180.2017.06
    Published on: 14 Jun 2017  | Viewed:2443  | Downloaded:128
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  • Original Article|Open Access

    Knowledge, awareness, and practice of forensic odontology among dental surgeons in Bhubaneswar, India

    Juber Rahman, Samapika Routray, Sudhanshu S. Mishra, Ipsita Mohanty, Neeta Mohanty, Narayan Sukla
    Aim: The aim of the study was to evaluate knowledge, awareness, and practice related to forensic odontology among dental surgeons in Bhubaneswar, East India. Methods: A blind cross-sectional study, using a questionnaire with close-ended questions, was carried out. Interns were included to assess their knowledge and practice (related to dental record keeping) while in an institutional setting. In addition, dentists with Bachelor of Dental Surgery (BDS) and Master of Dental Surgery (MDS) qualifications (irrespective of their specialty) were assessed, which included purely private... Read more
    J Unexplored Med Data 2017;2:26-33. | doi:10.20517/2572-8180.2017.01
    Published on: 21 May 2017  | Viewed:6184  | Downloaded:317
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  • Short Communication|Open Access

    Endoscopic dual versus monotherapy in patients bleeding from high-risk peptic ulcers

    Angelo Andriulli, Silvano Loperfido, Grazia Napolitano, Rosaria Focareta, Fabio Fornari, Antonietta Garripoli, Antonio Merla, Antonio Massimo Ippolito, Pietro Leo, Riccardo Marmo
    Aim: Dual endoscopic and pharmacologic therapy is currently the standard treatment for patients with high-risk peptic ulcer bleeding. The authors assess the efficacy of dual (endoscopic and pharmacologic) therapy versus endoscopic monotherapy in reducing rates of recurrent bleeding and death in patients with high-risk peptic bleeds. Methods: The authors carried out a post-hoc analysis of data on the use of intravenous proton pump inhibitors for the prevention of rebleeding ulcers and death (from an investigator-supported multicenter randomized trial in Italy). All the patients bleeding from... Read more
    J Unexplored Med Data 2017;2:20-5. | doi:10.20517/2572-8180.2016.11
    Published on: 30 Mar 2017  | Viewed:1429  | Downloaded:140
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Journal of Unexplored Medical Data ISSN 2572-8180 (Online)
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